Asymmetric N-Heterocyclic Carbene Catalyzed Annulation of 2-Alkenylbenzothiazoles with α-Chloro Aldehydes
نویسندگان
چکیده
Diastereo- and enantioselective N-heterocyclic carbene catalyzed 1-azadiene Diels-Alder reactions of (E)-2-styrylbenzothiazoles with α-chloro aldehydes are reported. This annulation strategy provides an efficient access to medicinally important dihydrobenzothiazolopyridin-1-ones in good to excellent yields (44-97%) with very good to excellent stereoselectivities (up to 9:1 dr, 98% ee) and tolerates quite a range of substituents.
منابع مشابه
Enantioselective synthesis of functionalized pyrazoles by NHC-catalyzed reaction of pyrazolones with α,β-unsaturated aldehydes.
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عنوان ژورنال:
دوره 47 شماره
صفحات -
تاریخ انتشار 2014